A universal biocompatible coating for enhanced lubrication and bacterial inhibition.
Biomater Sci
; 10(13): 3493-3502, 2022 Jun 28.
Article
em En
| MEDLINE
| ID: mdl-35593214
ABSTRACT
Antibacterial coatings that inhibit bacterial adhesion are essential for many implanted medical devices. A variety of antibacterial strategies, such as repelling or killing bacteria, have been developed, but not yet been completely successful. Here, we develop a universal biocompatible coating for enhanced lubrication and bacterial inhibition. The coating is designed based on mussel-inspired surface-attachable dopamine bases and consists of lubricating zwitterionic polymers poly(2-methacryloxyethyl phosphorylcholine) (MPC) and a bacterial membrane destroying anti-bacteria molecule poly(3-hydroxybutyric acid) (PHB). The coating boasts strong adhesion to surfaces of various materials (such as polydimethylsiloxane (PDMS)/ceramic/316L stainless steel (316L SS); it is biocompatible, and cell/platelet/bacteria repelling, significantly inhibiting bacterial growth. We envision that our strategy represents a universal strategy for surface functionalization of a variety of biomedical devices and implants.
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1
Base de dados:
MEDLINE
Assunto principal:
Fosforilcolina
/
Materiais Revestidos Biocompatíveis
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article