Selexipag Improves Lipopolysaccharide-Induced ARDS on C57BL/6 Mice by Modulating the cAMP/PKA and cAMP/Epac1 Signaling Pathways.

Chen, Hongliu; Shen, Ying; Liang, Yi; Qiu, Ying; Xu, Meili; Li, Chaoqian

Chen, Hongliu; Shen, Ying; Liang, Yi; Qiu, Ying; Xu, Meili; Li, Chaoqian.

Afiliação

Chen H; Department of Emergency, the First Affiliated Hospital of Guangxi Medical University.
Shen Y; General Practice School, Guangxi Medical University.
Liang Y; Department of Respiratory Medicine, the First Affiliated Hospital of Guangxi Medical University.
Qiu Y; Department of Emergency, the First Affiliated Hospital of Guangxi Medical University.
Xu M; Department of Emergency, the First Affiliated Hospital of Guangxi Medical University.
Li C; Department of Emergency, the First Affiliated Hospital of Guangxi Medical University.

Biol Pharm Bull ; 45(8): 1043-1052, 2022 Aug 01.

Article em En | MEDLINE | ID: mdl-35598975

Assuntos

Acetamidas; Pirazinas; Síndrome do Desconforto Respiratório; Acetamidas/farmacologia; Animais; Inflamação/metabolismo; Lipopolissacarídeos/toxicidade; Pulmão/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Pirazinas/farmacologia; Síndrome do Desconforto Respiratório/induzido quimicamente; Síndrome do Desconforto Respiratório/tratamento farmacológico; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Selexipag; acute respiratory distress syndrome; exchange protein activated by cAMP 1 (Epacl); protein kinase A (PKA)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazinas / Síndrome do Desconforto Respiratório / Acetamidas Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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