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Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.
Hoy, Michael J; Park, Eunchong; Lee, Hyunji; Lim, Won Young; Cole, D Christopher; DeBouver, Nicholas D; Bobay, Benjamin G; Pierce, Phillip G; Fox, David; Ciofani, Maria; Juvvadi, Praveen R; Steinbach, William; Hong, Jiyong; Heitman, Joseph.
Afiliação
  • Hoy MJ; Department of Molecular Genetics and Microbiology, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA.
  • Park E; Department of Immunology, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA.
  • Lee H; Department of Chemistry, Duke Universitygrid.26009.3d, Durham, North Carolina, USA.
  • Lim WY; Department of Chemistry, Duke Universitygrid.26009.3d, Durham, North Carolina, USA.
  • Cole DC; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA.
  • DeBouver ND; UCB Biosciences, Bainbridge Island, Washington, USA.
  • Bobay BG; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.
  • Pierce PG; Duke Universitygrid.26009.3d NMR Center, Durham, North Carolina, USA.
  • Fox D; UCB Biosciences, Bainbridge Island, Washington, USA.
  • Ciofani M; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.
  • Juvvadi PR; UCB Biosciences, Bainbridge Island, Washington, USA.
  • Steinbach W; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.
  • Hong J; Department of Immunology, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA.
  • Heitman J; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke Universitygrid.26009.3d Medical Center, Durham, North Carolina, USA.
mBio ; 13(3): e0104922, 2022 06 28.
Article em En | MEDLINE | ID: mdl-35604094
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tacrolimo / Cryptococcus neoformans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tacrolimo / Cryptococcus neoformans Idioma: En Ano de publicação: 2022 Tipo de documento: Article