Effects of atrazine and diuron on life parameters, antioxidant response, and multixenobiotic resistance in non-targeted marine zooplankton.
Comp Biochem Physiol C Toxicol Pharmacol
; 258: 109378, 2022 Aug.
Article
em En
| MEDLINE
| ID: mdl-35605931
ABSTRACT
Atrazine and diuron are among the most widely used antifoulant biocides in the world. Due to their persistence in the environment, they can induce adverse effects on non-targeted organisms. In this study, we investigated the chronic in vivo toxicity of atrazine and diuron with further assessments on oxidative stress responses (e.g., oxidative stress, antioxidant) and multixenobiotic resistance (MXR) function in the rotifer Brachionus koreanus, a non-targeted microzooplanktonic grazer at the primary level of the marine food chain. Although similar oxidative response was shown by both biocides, diuron induced stronger retardation on reproduction and population growth rates of B. koreanus while moderate effects were observed by atrazine. This higher toxicity of diuron was shown to be associated with its stronger inhibition of MXR conferred by P-glycoprotein and multidrug resistance proteins which play as a first line of defense by transporting various toxicants out of a cell. Our study provides new insight into non-targeted effects of biocides on marine zooplankton and mechanisms beyond their different degrees of toxicity.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Rotíferos
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Atrazina
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Poluentes Químicos da Água
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Desinfetantes
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article