Penicillanic Acid Sulfones Inactivate the Extended-Spectrum ß-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of ß-Lactamase Inhibition.

Hinchliffe, Philip; Tooke, Catherine L; Bethel, Christopher R; Wang, Benlian; Arthur, Christopher; Heesom, Kate J; Shapiro, Stuart; Schlatzer, Daniela M; Papp-Wallace, Krisztina M; Bonomo, Robert A; Spencer, James

Hinchliffe, Philip; Tooke, Catherine L; Bethel, Christopher R; Wang, Benlian; Arthur, Christopher; Heesom, Kate J; Shapiro, Stuart; Schlatzer, Daniela M; Papp-Wallace, Krisztina M; Bonomo, Robert A; Spencer, James.

Afiliação

Hinchliffe P; School of Cellular and Molecular Medicine, University of Bristolgrid.5337.2, Bristol, United Kingdom.
Tooke CL; School of Cellular and Molecular Medicine, University of Bristolgrid.5337.2, Bristol, United Kingdom.
Bethel CR; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.
Wang B; Department of Proteomics and Bioinformatics, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.
Arthur C; School of Chemistry, University of Bristolgrid.5337.2, Bristol, United Kingdom.
Heesom KJ; Proteomics Facility, Faculty of Life Sciences, University of Bristolgrid.5337.2, Bristol, United Kingdom.
Shapiro S; Allecra Therapeutics SAS, Saint-Louis, France.
Schlatzer DM; Department of Proteomics and Bioinformatics, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.
Papp-Wallace KM; Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA.
Bonomo RA; Department of Medicine, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.
Spencer J; Department of Biochemistry, Case Western Reserve Universitygrid.67105.35 School of Medicine, Cleveland, Ohio, USA.

mBio ; 13(3): e0179321, 2022 06 28.

Article em En | MEDLINE | ID: mdl-35612361

Assuntos

Sulbactam; Inibidores de beta-Lactamases; Antibacterianos/farmacologia; Lisina; Testes de Sensibilidade Microbiana; Serina; Sulbactam/farmacologia; Tazobactam/farmacologia; Inibidores de beta-Lactamases/farmacologia; beta-Lactamases/metabolismo

Palavras-chave

AAI101; CTX-M-15; antibiotic resistance; enmetazobactam; extended-spectrum ß-lactamase; inhibitor; lysinoalanine; tazobactam

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulbactam / Inibidores de beta-Lactamases Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulbactam / Inibidores de beta-Lactamases Idioma: En Ano de publicação: 2022 Tipo de documento: Article