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UPF1 adds an m6A feather to its (de)cap.
Gibbs, Michelle R; Chanfreau, Guillaume F.
Afiliação
  • Gibbs MR; Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095-1569, USA.
  • Chanfreau GF; Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095-1569, USA. Electronic address: guillom@chem.ucla.edu.
Cell Rep ; 39(8): 110898, 2022 05 24.
Article em En | MEDLINE | ID: mdl-35613576
ABSTRACT
The N6-methyladenosine modification (m6A) modulates eukaryotic mRNA decay. In this issue of Cell Reports, Boo et al. describe a mechanism for degradation of m6A-containing mRNAs by 5'-decapping, which occurs through the recruitment of the degradation factor UPF1 via the m6A reader protein YTHDF2.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenosina / Proteínas de Ligação a RNA Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenosina / Proteínas de Ligação a RNA Idioma: En Ano de publicação: 2022 Tipo de documento: Article