Neat1 promotes acute kidney injury to chronic kidney disease by facilitating tubular epithelial cells apoptosis via sequestering miR-129-5p.

Ma, Tongtong; Li, Hongwei; Liu, Hui; Peng, Yili; Lin, Tong; Deng, Zhiya; Jia, Nan; Chen, Zhongqing; Wang, Peng

Ma, Tongtong; Li, Hongwei; Liu, Hui; Peng, Yili; Lin, Tong; Deng, Zhiya; Jia, Nan; Chen, Zhongqing; Wang, Peng.

Afiliação

Ma T; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Li H; Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou 510515,
Liu H; Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Peng Y; Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou 510515,
Lin T; Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou 510515,
Deng Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Jia N; Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou 510515,
Chen Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Wang P; Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou 510515,

Mol Ther ; 30(10): 3313-3332, 2022 10 05.

Article em En | MEDLINE | ID: mdl-35619557

Assuntos

Injúria Renal Aguda; MicroRNAs; RNA Longo não Codificante; Insuficiência Renal Crônica; Injúria Renal Aguda/genética; Injúria Renal Aguda/metabolismo; Apoptose/genética; Células Epiteliais/metabolismo; Fibrose; Humanos; MicroRNAs/genética; MicroRNAs/metabolismo; RNA Longo não Codificante/genética; RNA Longo não Codificante/metabolismo; Insuficiência Renal Crônica/genética; Insuficiência Renal Crônica/metabolismo; Insuficiência Renal Crônica/patologia; Proteína Supressora de Tumor p53/metabolismo

Palavras-chave

ESRD; acute kidney injury; apoptosis; chronic kidney disease; ischemic-reperfusion injury; long noncoding RNA; microRNA; renal fibrosis; tubular epithelial cell; tubulointerstitial fibrosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Insuficiência Renal Crônica / Injúria Renal Aguda / RNA Longo não Codificante Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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