Glycerosomal thermosensitive in situ gel of duloxetine HCl as a novel nanoplatform for rectal delivery: in vitro optimization and in vivo appraisal.

Salem, Heba F; Ali, Adel A; Rabea, Yasmine K; El-Ela, Fatma I Abo; Khallaf, Rasha A

Salem, Heba F; Ali, Adel A; Rabea, Yasmine K; El-Ela, Fatma I Abo; Khallaf, Rasha A.

Afiliação

Salem HF; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Ali AA; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Rabea YK; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
El-Ela FIA; Department of Pharmacology, Faculty of Veterinary Medicine, Beni-Suef University, Egypt, 62511, Egypt.
Khallaf RA; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt. rasha.mahmoud@pharm.bsu.edu.eg.

Drug Deliv Transl Res ; 12(12): 3083-3103, 2022 12.

Article em En | MEDLINE | ID: mdl-35622235

Assuntos

Transtorno Depressivo Maior; Portadores de Fármacos; Animais; Ratos; Cloridrato de Duloxetina; Portadores de Fármacos/farmacocinética; Géis; Disponibilidade Biológica; Tamanho da Partícula; Sistemas de Liberação de Medicamentos

Palavras-chave

Depression; Duloxetine HCl; Glycerosomes; Pharmacokinetics, Pharmacodynamics, Thermosensitive in situ gel; Rectal delivery

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Portadores de Fármacos / Transtorno Depressivo Maior Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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