Single-cell transcriptomics profiling the compatibility mechanism of As<sub>2</sub>O<sub>3</sub>-indigo naturalis formula based on bone marrow stroma cells.

Zhang, Xianxie; Chen, Hebing; Huang, Xin; Xu, Huanhua; Li, Yaru; Yuan, Hailong; Yu, Jia; Gao, Yue

Single-cell transcriptomics profiling the compatibility mechanism of As₂O₃-indigo naturalis formula based on bone marrow stroma cells.

Zhang, Xianxie; Chen, Hebing; Huang, Xin; Xu, Huanhua; Li, Yaru; Yuan, Hailong; Yu, Jia; Gao, Yue.

Afiliação

Zhang X; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medici
Chen H; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Huang X; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Xu H; Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Li Y; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Yuan H; Air Force Medical Center of PLA, Beijing, China. Electronic address: yhlpharm@126.com.
Yu J; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China. Electronic address: j-yu@ibms.pumc.edu.cn.
Gao Y; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: gaoyue@bmi.ac.cn.

Biomed Pharmacother ; 151: 113182, 2022 Jul.

Article em En | MEDLINE | ID: mdl-35643069

Assuntos

Antineoplásicos; Arsenicais; Leucemia Promielocítica Aguda; Células-Tronco Mesenquimais; Animais; Antineoplásicos/uso terapêutico; Arsenicais/uso terapêutico; Medula Óssea; Índigo Carmim/uso terapêutico; Leucemia Promielocítica Aguda/tratamento farmacológico; Camundongos; Osteogênese; Óxidos/uso terapêutico; Transcriptoma; Microambiente Tumoral

Palavras-chave

Acute promyelocytic leukemia (APL); As(2)O(3)-indigo naturalis formula; Bone marrow stroma cells; Compatibility; Single-cell RNA sequencing (scRNA-seq)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arsenicais / Leucemia Promielocítica Aguda / Células-Tronco Mesenquimais / Antineoplásicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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