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Triazine-pyridine chemistry for protein labelling on tyrosine.
Jiang, Hongfei; Zhang, Qing; Zhang, Yue; Feng, Huxin; Jiang, Hao; Pu, Fan; Yu, Rilei; Zhong, Zheng; Wang, Chaoming; Fung, Yi Man Eva; Blasco, Pilar; Li, Yongxin; Jiang, Tao; Li, Xuechen.
Afiliação
  • Jiang H; Key Laboratory of Marine Drugs Chinese Ministry of Education, Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. jiangtao@ouc.edu.cn.
  • Zhang Q; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China. xuechenl@hku.hk.
  • Zhang Y; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China. xuechenl@hku.hk.
  • Feng H; Key Laboratory of Marine Drugs Chinese Ministry of Education, Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. jiangtao@ouc.edu.cn.
  • Jiang H; Key Laboratory of Marine Drugs Chinese Ministry of Education, Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. jiangtao@ouc.edu.cn.
  • Pu F; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China. xuechenl@hku.hk.
  • Yu R; Key Laboratory of Marine Drugs Chinese Ministry of Education, Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. jiangtao@ouc.edu.cn.
  • Zhong Z; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China. xuechenl@hku.hk.
  • Wang C; Key Laboratory of Marine Drugs Chinese Ministry of Education, Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. jiangtao@ouc.edu.cn.
  • Fung YME; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China. xuechenl@hku.hk.
  • Blasco P; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China. xuechenl@hku.hk.
  • Li Y; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China. xuechenl@hku.hk.
  • Jiang T; Key Laboratory of Marine Drugs Chinese Ministry of Education, Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. jiangtao@ouc.edu.cn.
  • Li X; Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China. xuechenl@hku.hk.
Chem Commun (Camb) ; 58(50): 7066-7069, 2022 Jun 21.
Article em En | MEDLINE | ID: mdl-35648412
ABSTRACT
Herein, we discover the new reactivity of the 1,3,5-triazine moiety reacting with a phenol group and report the development of biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine labelling under physiological conditions and profiling in the whole proteome. TPC exhibited high tyrosine chemoselectivity in biological systems after cysteine blocking, displayed potential in tyrosine-guided protein labelling, and had bio-compatibility in live cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tirosina / Triazinas Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tirosina / Triazinas Idioma: En Ano de publicação: 2022 Tipo de documento: Article