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Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
Lopez, Juan Pablo; Lücken, Malte D; Brivio, Elena; Karamihalev, Stoyo; Kos, Aron; De Donno, Carlo; Benjamin, Asaf; Yang, Huanqing; Dick, Alec L W; Stoffel, Rainer; Flachskamm, Cornelia; Ressle, Andrea; Roeh, Simone; Huettl, Rosa-Eva; Parl, Andrea; Eggert, Carola; Novak, Bozidar; Yan, Yu; Yeoh, Karin; Holzapfel, Maria; Hauger, Barbara; Harbich, Daniela; Schmid, Bianca; Di Giaimo, Rossella; Turck, Christoph W; Schmidt, Mathias V; Deussing, Jan M; Eder, Matthias; Dine, Julien; Theis, Fabian J; Chen, Alon.
Afiliação
  • Lopez JP; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Lücken MD; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Bavaria, Germany.
  • Brivio E; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Karamihalev S; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Kos A; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • De Donno C; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Bavaria, Germany.
  • Benjamin A; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot 76100, Israel.
  • Yang H; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Dick ALW; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Stoffel R; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Flachskamm C; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Ressle A; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Roeh S; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Huettl RE; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Parl A; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Eggert C; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Novak B; Proteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Yan Y; Proteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Yeoh K; Proteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Holzapfel M; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Hauger B; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Harbich D; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Schmid B; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Di Giaimo R; Department of Developmental Neurobiology, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Turck CW; Proteomics and Biomarkers, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Schmidt MV; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Deussing JM; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Eder M; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany.
  • Dine J; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
  • Theis FJ; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764 Bavaria, Germany.
  • Chen A; Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, 80804 Bavaria, Germany; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot 76100, Israel. Ele
Neuron ; 110(14): 2283-2298.e9, 2022 07 20.
Article em En | MEDLINE | ID: mdl-35649415
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ketamina Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ketamina Idioma: En Ano de publicação: 2022 Tipo de documento: Article