Ischemic stroke with cancer: Hematologic and embolic biomarkers and clinical outcomes.
J Thromb Haemost
; 20(9): 2046-2057, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35652416
ABSTRACT
BACKGROUND:
Patients with cancer and acute ischemic stroke (AIS) face high rates of recurrent thromboembolism or death.OBJECTIVES:
To examine whether hematologic and embolic biomarkers soon after AIS are associated with subsequent adverse clinical outcomes.METHODS:
We prospectively enrolled 50 adults with active solid tumor cancer and AIS at two hospitals from 2016 to 2020. Blood was collected 72-120 h after stroke onset. A 30-min transcranial Doppler (TCD) microemboli detection study was performed. The exposure variables were hematologic markers of coagulation (D-dimer, thrombin-antithrombin), platelet (P-selectin), and endothelial activation (thrombomodulin, soluble intercellular adhesion molecule-1 [sICAM-1], soluble vascular cell adhesion molecule-1 [sVCAM-1]), and the presence of TCD microemboli. The primary outcome was a composite of recurrent arterial/venous thromboembolism or death. We used Cox regression to evaluate associations between biomarkers and subsequent outcomes.RESULTS:
During an estimated median follow-up time of 48 days (IQR, 18-312), 43 (86%) participants developed recurrent thromboembolism or death, including 28 (56%) with recurrent thromboembolism, of which 13 were recurrent AIS (26%). In unadjusted analysis, D-dimer (HR 1.6; 95% CI 1.2-2.0), P-selectin (HR 1.9; 95% CI 1.4-2.7), sICAM-1 (HR 2.2; 95% CI 1.6-3.1), sVCAM-1 (HR 1.6; 95% CI 1.2-2.1), and microemboli (HR 2.2; 95% CI 1.1-4.5) were associated with the primary outcome, whereas thrombin-antithrombin and thrombomodulin were not. D-dimer was the only marker associated with recurrent AIS (HR 1.2; 95% CI 1.0-1.5). Results were generally consistent in analyses adjusted for important prognostic variables.CONCLUSIONS:
Markers of hypercoagulability and embolic disease may be associated with adverse clinical outcomes in cancer-related stroke.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tromboembolia
/
AVC Isquêmico
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Neoplasias
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article