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Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism.
Chen, F; Elgaher, W A M; Winterhoff, M; Büssow, K; Waqas, F H; Graner, E; Pires-Afonso, Y; Casares Perez, L; de la Vega, L; Sahini, N; Czichon, L; Zobl, W; Zillinger, T; Shehata, M; Pleschka, S; Bähre, H; Falk, C; Michelucci, A; Schuchardt, S; Blankenfeldt, W; Hirsch, A K H; Pessler, F.
Afiliação
  • Chen F; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Elgaher WAM; Research Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Winterhoff M; Helmholtz Institute for Pharmaceutical Research Saarland - Helmholtz Centre for Infection Research, Saarbrücken, Germany.
  • Büssow K; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Waqas FH; Research Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Graner E; Department of Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Pires-Afonso Y; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Casares Perez L; Research Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • de la Vega L; Department of Structure and Function of Proteins, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Sahini N; Neuro-Immunology Group, Department of Cancer Research, LIH Luxembourg Institute of Health, Luxembourg, Luxembourg.
  • Czichon L; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-Belval, Luxembourg.
  • Zobl W; Division of Molecular Medicine, University of Dundee, Dundee, UK.
  • Zillinger T; Division of Molecular Medicine, University of Dundee, Dundee, UK.
  • Shehata M; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Pleschka S; Research Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Bähre H; Research Group Biomarkers for Infectious Diseases, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Falk C; Research Group Biomarkers for Infectious Diseases, TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany.
  • Michelucci A; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany.
  • Schuchardt S; Institute of Clinical Chemistry and Clinical Pharmacology, University Medical Centre Bonn, Bonn, Germany.
  • Blankenfeldt W; Institute of Immunology, Philipps-University Marburg, Marburg, Germany.
  • Hirsch AKH; Institute of Medical Virology, Justus-Liebig-University Giessen, Giessen, Germany.
  • Pessler F; National Research Centre, Giza, Egypt.
Nat Metab ; 4(5): 534-546, 2022 05.
Article em En | MEDLINE | ID: mdl-35655026
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interferons / Fumaratos / Macrófagos / Maleatos Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interferons / Fumaratos / Macrófagos / Maleatos Idioma: En Ano de publicação: 2022 Tipo de documento: Article