Toosendanin inhibits colorectal cancer cell growth through the Hedgehog pathway by targeting Shh.

Zhang, Meng; Tao, Zhongyi; Gao, Lijuan; Chen, Fengyang; Ye, Yiping; Xu, Shifang; Huang, Wenkang; Li, Xiaoyu

Zhang, Meng; Tao, Zhongyi; Gao, Lijuan; Chen, Fengyang; Ye, Yiping; Xu, Shifang; Huang, Wenkang; Li, Xiaoyu.

Afiliação

Zhang M; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Tao Z; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Gao L; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Chen F; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Ye Y; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Xu S; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Huang W; School of Pharmaceutical Sciences, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Li X; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Drug Dev Res ; 83(5): 1201-1211, 2022 08.

Article em En | MEDLINE | ID: mdl-35656621

Assuntos

Neoplasias Colorretais; Medicamentos de Ervas Chinesas; Apoptose; Linhagem Celular Tumoral; Neoplasias Colorretais/tratamento farmacológico; Medicamentos de Ervas Chinesas/farmacologia; Proteínas Hedgehog; Humanos; Triterpenos

Palavras-chave

HT29 cells; Hedgehog signaling pathway; Shh ligand; Toosendanin; colorectal cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Neoplasias Colorretais Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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