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A case of anti-laminin gamma-1 (p200) pemphigoid with bullous lesions on the lips, hands and feet showing antibodies to desmoglein 1.
Kaneko, F; Ozasa, M; Togashi, A.
Afiliação
  • Kaneko F; Dermatology Unit Southern TOHOKU General Hospital Southern TOHOKU Research Institute for Neuroscience Koriyama Japan.
  • Ozasa M; Dermatology Unit Southern TOHOKU General Hospital Southern TOHOKU Research Institute for Neuroscience Koriyama Japan.
  • Togashi A; Dermatology Unit Southern TOHOKU General Hospital Southern TOHOKU Research Institute for Neuroscience Koriyama Japan.
Skin Health Dis ; 2(1): e101, 2022 Mar.
Article em En | MEDLINE | ID: mdl-35665215
An 87-years-old-man presented with bullous and erosive lesions exclusively on the lips, hands and feet. Histopathological and direct immunofluorescence studies suggested the diagnosis of bullous pemphigoid, but the serum anti-BP180 antibodies were negative. Strangely, anti-desmoglein 1 antibodies were positive, although no pemphigus-like features were found. Indirect immunofluorescence showed IgG reactivity with dermal side of 1 M NaCl-split skin. Immunoblotting showed positive reactivity with the 200 kDa laminin gamma-1 but not with type VII collagen. After the administration of prednisolone 20 mg/day, bullous lesions cleared within 2 weeks.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article