WEE1 kinase inhibitor MK-1775 sensitizes oral tongue squamous cell carcinoma cells to radiation irrespective of TP53 status.

Al-Jamaei, Aisha Hussein; de Visscher, Jan G A M; Subramanyam, V Ramadugula; Forouzanfar, Tymour; Sminia, Peter; Doulabi, Behrouz Zandieh; Helder, Marco N

Al-Jamaei, Aisha Hussein; de Visscher, Jan G A M; Subramanyam, V Ramadugula; Forouzanfar, Tymour; Sminia, Peter; Doulabi, Behrouz Zandieh; Helder, Marco N.

Afiliação

Al-Jamaei AH; Department of Oral and Maxillofacial Surgery and Oral Pathology, Amsterdam UMC-location VUmc/Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands.
de Visscher JGAM; Department of Oral and Maxillofacial Surgery and Oral Pathology, Amsterdam UMC-location VUmc/Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands.
Subramanyam VR; Department of OMFS and Diagnostic Sciences, College of Dentistry, King Faisal University, Al Hofuf, Saudi Arabia.
Forouzanfar T; Department of Oral and Maxillofacial Surgery and Oral Pathology, Amsterdam UMC-location VUmc/Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands.
Sminia P; Department of Radiation Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Doulabi BZ; Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam-University of Amsterdam and VU Amsterdam, Amsterdam, The Netherlands.
Helder MN; Department of Oral and Maxillofacial Surgery and Oral Pathology, Amsterdam UMC-location VUmc/Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands.

Oral Dis ; 29(7): 2640-2649, 2023 Oct.

Article em En | MEDLINE | ID: mdl-35672254

Assuntos

Antineoplásicos; Carcinoma de Células Escamosas; Neoplasias de Cabeça e Pescoço; Neoplasias da Língua; Humanos; Carcinoma de Células Escamosas de Cabeça e Pescoço; Pirimidinas/farmacologia; Proteína Supressora de Tumor p53/genética; Carcinoma de Células Escamosas/radioterapia; Proteínas de Ciclo Celular/genética; Proteínas Tirosina Quinases/genética; Proteínas Tirosina Quinases/metabolismo; Proteínas Nucleares/metabolismo; Linhagem Celular Tumoral; Neoplasias da Língua/radioterapia; Antineoplásicos/farmacologia; Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos da radiação; Apoptose

Palavras-chave

MK-1775; Oral tongue squamous cell carcinoma; Wee1 kinase inhibitor; p53; radiation; radiosensitization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Língua / Carcinoma de Células Escamosas / Neoplasias de Cabeça e Pescoço / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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