Role of anti-TNF in Pediatric Inflammatory Choroidal Neovascularization: A Case Series.
Ocul Immunol Inflamm
; 31(5): 1006-1012, 2023 Jul.
Article
em En
| MEDLINE
| ID: mdl-35675035
ABSTRACT
OBJECTIVE:
To highlight the safety and efficacy of Tumor Necrosis Factor inhibitors (anti-TNF) in inflammatory choroidal neovascularization (CNV) in the pediatric population.DESIGN:
Retrospective case series.PARTICIPANTS:
Three patients, < 16 years old with uveitic inflammatory CNV.METHODS:
Patients received systemic steroids, methotrexate (MTX), intravitreal (IVT) injections of bevacizumab, and anti-TNF (infliximab or adalimumab) in case of refractory leakage.RESULTS:
Five eyes of three pediatric patients (mean age 6 years old) presenting with CNV and put on anti-TNF were followed up for a minimum of 32 months. Four out of five eyes had improved vision, reduced fluid on clinical exam and macular spectral-domain optical coherence tomography (SD-OCT), and cessation of leakage on fundus fluorescein angiography (FFA) after introduction of anti-TNF agents. Two patients developed minor psoriasis treated topically.CONCLUSION:
Anti-TNF agents showed efficacy and safety in a sustainable leakage control of inflammatory pediatric CNV along with improvement in vision.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neovascularização de Coroide
/
Inibidores da Angiogênese
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article