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Role of IL-36 cytokines in psoriasis and other inflammatory skin conditions.
Sachen, Kacey L; Arnold Greving, Carrie N; Towne, Jennifer E.
Afiliação
  • Sachen KL; Immunology Discovery, Janssen Research and Development, San Diego, CA 92121, USA.
  • Arnold Greving CN; Immunology Discovery, Janssen Research and Development, San Diego, CA 92121, USA.
  • Towne JE; Immunology Discovery, Janssen Research and Development, San Diego, CA 92121, USA. Electronic address: jtowne1@its.jnj.com.
Cytokine ; 156: 155897, 2022 08.
Article em En | MEDLINE | ID: mdl-35679693
ABSTRACT
The IL-36 family of cytokines includes three pro-inflammatory agonists (IL-36α, IL-36ß, and IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric receptor composed of IL-36R and the IL-1R accessory protein (IL-1RAcP). Individuals with inactivating mutations in the gene encoding IL-36Ra develop generalized pustular psoriasis, a severe form of psoriasis, a finding which clearly links dysregulated IL-36 pathway activation to inflammatory skin conditions. The purpose of this review is to highlight the cellular source of IL-36 cytokines, the effects of IL-36 signaling across cell types, and the association of IL-36 to a spectrum of inflammatory skin diseases including various forms of psoriasis as well as hidradenitis suppurativa, atopic dermatitis, and allergic contact dermatitis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Psoríase / Hidradenite Supurativa Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Psoríase / Hidradenite Supurativa Idioma: En Ano de publicação: 2022 Tipo de documento: Article