Evaluation of short-term epigenetic age fluctuation.
Clin Epigenetics
; 14(1): 76, 2022 06 09.
Article
em En
| MEDLINE
| ID: mdl-35681206
ABSTRACT
Considerable effort has been spent on lowering and maintaining the epigenetic age. However, the extent to which epigenetic age fluctuates under normal conditions is poorly understood. Therefore, we analyzed methylation data from monocytes and peripheral blood mononuclear cells collected from two Japanese men. The ranges of the Pan-tissue, Skin and blood, and DNAm PhenoAge epigenetic age during 3 months were ≥ 5.62, ≥ 3.04, and ≥ 8.23 years, and the maximum daily changes were 5.21, 3.20, and 6.53 years, respectively. These fluctuations were not suppressed by correcting for cell-type composition. Although the underlying biological mechanism remains unclear, there was a nonnegligible degree of age fluctuation which should inform personalized clinical applications.
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Base de dados:
MEDLINE
Assunto principal:
Metilação de DNA
/
Epigênese Genética
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article