Transplantation of Roxadustat-preconditioned bone marrow stromal cells improves neurological function recovery through enhancing grafted cell survival in ischemic stroke rats.

Chen, Jiayu; Lin, Xiao; Yao, Chaojie; Bingwa, Lebohang Anesu; Wang, Hao; Lin, Zhongxiao; Jin, Kunlin; Zhuge, Qichuan; Yang, Su

Chen, Jiayu; Lin, Xiao; Yao, Chaojie; Bingwa, Lebohang Anesu; Wang, Hao; Lin, Zhongxiao; Jin, Kunlin; Zhuge, Qichuan; Yang, Su.

Afiliação

Chen J; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Lin X; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yao C; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Bingwa LA; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Wang H; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Lin Z; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jin K; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Zhuge Q; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yang S; Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

CNS Neurosci Ther ; 28(10): 1519-1531, 2022 10.

Article em En | MEDLINE | ID: mdl-35695696

Assuntos

Isquemia Encefálica; AVC Isquêmico; Transplante de Células-Tronco Mesenquimais; Células-Tronco Mesenquimais; Acidente Vascular Cerebral; Animais; Células da Medula Óssea/metabolismo; Transplante de Medula Óssea; Isquemia Encefálica/tratamento farmacológico; Isquemia Encefálica/metabolismo; Sobrevivência Celular; Glicina/análogos & derivados; Infarto da Artéria Cerebral Média/metabolismo; Infarto da Artéria Cerebral Média/terapia; Isoquinolinas; Células-Tronco Mesenquimais/metabolismo; Ratos; Ratos Sprague-Dawley; Recuperação de Função Fisiológica/fisiologia; Acidente Vascular Cerebral/tratamento farmacológico; Acidente Vascular Cerebral/metabolismo

Palavras-chave

HIF-1α/BNIP3 signal pathway; autophagy; bone marrow stromal cells; stroke

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Acidente Vascular Cerebral / Transplante de Células-Tronco Mesenquimais / Células-Tronco Mesenquimais / AVC Isquêmico Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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