Anti-Saccharomyces cerevisiae Antibodies in Rheumatoid Arthritis.
Lab Med
; 53(6): 585-589, 2022 Nov 03.
Article
em En
| MEDLINE
| ID: mdl-35699491
ABSTRACT
OBJECTIVE:
This study was conducted to evaluate the frequency of anti-Saccharomyces cerevisiae antibodies (ASCA) in patients with rheumatoid arthritis (RA).METHODS:
Eighty-three RA patients with positive anti-cyclic citrullinated antibodies (anti-CCP) and 160 healthy blood donors were included in this study. ASCA IgG and IgA were assessed with enzyme-linked immunosorbent assay.RESULTS:
The frequency of ASCA was significantly higher in RA patients than in healthy subjects (22.9% vs 3.7%, Pâ <â 10-3). Both ASCA IgG and ASCA IgA were significantly more frequent in RA patients than in the control group (20.5% vs 3.1%, Pâ <â 10-3and 9.6% vs 0.6%, Pâ =â .002, respectively). ASCA IgG and ASCA IgA levels were significantly higher in RA patients than in healthy subjects (7.8â ±â 8.4 U/mL vs 2.3â ±â 2.8 U/mL, Pâ <â 10-6 and 6.2â ±â 10.9 U/mL vs 3.4â ±â 1.7 U/mL, Pâ =â .002, respectively).CONCLUSION:
A high frequency of ASCA IgG and ASCA IgA has been found in RA patients.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Imunoglobulina A
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article