Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.

Qin, Bo; Craven, Gregory B; Hou, Pengjiao; Chesti, Julian; Lu, Xinran; Child, Emma S; Morgan, Rhodri M L; Niu, Wenchao; Zhao, Lina; Armstrong, Alan; Mann, David J; Cui, Sheng

Qin, Bo; Craven, Gregory B; Hou, Pengjiao; Chesti, Julian; Lu, Xinran; Child, Emma S; Morgan, Rhodri M L; Niu, Wenchao; Zhao, Lina; Armstrong, Alan; Mann, David J; Cui, Sheng.

Afiliação

Qin B; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100076, China.
Craven GB; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Hou P; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100076, China.
Chesti J; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, UK.
Lu X; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, UK.
Child ES; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Morgan RML; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Niu W; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhao L; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, University of Chinese Academy of Sciences, Beijing 100049, China.
Armstrong A; Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London W12 0BZ, UK.
Mann DJ; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Cui S; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100076, China.