The Protective Effect of Sweet Potato Root Tuber on Chemotherapy-Induced Thrombocytopenia.
Mol Nutr Food Res
; 66(16): e2200126, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35712860
ABSTRACT
SCOPE Sweet potato (Ipomoea batatas L.) is one of the leading crops worldwide, containing high nutritional components such as fiber and polyphenols. Root tuber of Simon 1 (SIMON), a cultivar of sweet potato, is a folk food in China with a hemostasis function but lacking experimental data support. METHODS AND RESULTS:
Now the protective effect of SIMON on chemotherapy-induced thrombocytopenia (CIT), a serious complication of cancer treatment, is investigated for the first time by a CIT mouse model induced by intraperitoneal injection of carboplatin. As a result, SIMON raises the number of peripheral platelets, white blood cells, and bone marrow nucleated cells in CIT mice significantly. Besides, carboplatin-induced atrophy of the thymus, spleen, and disordered metabolism of the inflammatory immune system and glycerophospholipids are also reversed by SIMON. Phytochemical analysis of SIMON indicates 16 compounds including eight phenolic derivatives, which might be associated with its anti-CIT bioactivity.CONCLUSION:
Sweet potato (SIMON) may be an efficient function food in the prevention of bleeding disorders.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trombocitopenia
/
Ipomoea batatas
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article