Adhesion molecule Amigo2 is involved in the fasciculation process of the fasciculus retroflexus.
Dev Dyn
; 251(11): 1834-1847, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-35727300
ABSTRACT
BACKGROUND:
The fasciculus retroflexus is the prominent efferent pathway from the habenular complex. Medial habenular axons form a core packet whereas lateral habenular axons course in a surrounding shell. Both groups of fibers share the same initial pathway but differ in the final segment of the tract, supposedly regulated by surface molecules. The gene Amigo2 codes for a membrane adhesion molecule with an immunoglobulin-like domain 2 and is selectively expressed in the medial habenula. We present it as a candidate for controlling the fasciculation behavior of medial habenula axons.RESULTS:
First, we studied the development of the habenular efferents in an Amigo2 lack of function mouse model. The fasciculus retroflexus showed a variable defasciculation phenotype. Gain of function experiments allowed us to generate a more condensed tract and rescued the Amigo2 knock-out phenotype. Changes in Amigo2 function did not alter the course of habenular fibers.CONCLUSION:
We have demonstrated that Amigo2 plays a subtle role in the fasciculation of the fasciculus retroflexus.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Habenula
/
Fasciculação
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article