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CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia.
Grey, William; Rio-Machin, Ana; Casado, Pedro; Grönroos, Eva; Ali, Sara; Miettinen, Juho J; Bewicke-Copley, Findlay; Parsons, Alun; Heckman, Caroline A; Swanton, Charles; Cutillas, Pedro R; Gribben, John; Fitzgibbon, Jude; Bonnet, Dominique.
Afiliação
  • Grey W; Haematopoietic Stem Cell Laboratory, Francis Crick Institute, London NW1 1AT, UK.
  • Rio-Machin A; York Biomedical Research Institute, Department of Biology, University of York, York YO10 5DD, UK.
  • Casado P; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
  • Grönroos E; Cell Signaling and Proteomics Group, Center for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
  • Ali S; Cancer Evolution and Genome Instability Laboratory, Francis Crick Institute, London NW1 1AT, UK.
  • Miettinen JJ; Haematopoietic Stem Cell Laboratory, Francis Crick Institute, London NW1 1AT, UK.
  • Bewicke-Copley F; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.
  • Parsons A; Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
  • Heckman CA; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.
  • Swanton C; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Helsinki, Finland.
  • Cutillas PR; Cancer Evolution and Genome Instability Laboratory, Francis Crick Institute, London NW1 1AT, UK.
  • Gribben J; UCL Cancer Institute, 72 Huntley St. WC1E 6DD London, UK.
  • Fitzgibbon J; Cell Signaling and Proteomics Group, Center for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
  • Bonnet D; Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Sci Transl Med ; 14(650): eabn3248, 2022 06 22.
Article em En | MEDLINE | ID: mdl-35731890
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Quinases relacionadas a CDC2 e CDC28 Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Quinases relacionadas a CDC2 e CDC28 Idioma: En Ano de publicação: 2022 Tipo de documento: Article