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Identification of novel indole derivatives as highly potent and efficacious LSD1 inhibitors.
Zhang, Xiangyu; Sun, Yixiang; Huang, Hailan; Wang, Xinran; Wu, Tianxiao; Yin, Wenbo; Li, Xiaojia; Wang, Lin; Gu, Yanting; Zhao, Dongmei; Cheng, Maosheng.
Afiliação
  • Zhang X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Sun Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
  • Huang H; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, China.
  • Wang X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Chaoyang District, Beijing, 102488, China.
  • Wu T; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
  • Yin W; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
  • Li X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
  • Wang L; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
  • Gu Y; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, China. Electronic address: yanting-gu@163.com.
  • Zhao D; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China. Electronic address: dongmeiz-67@163.com.
  • Cheng M; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
Eur J Med Chem ; 239: 114523, 2022 Sep 05.
Article em En | MEDLINE | ID: mdl-35732082
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Histona Desmetilases / Indóis Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Histona Desmetilases / Indóis Idioma: En Ano de publicação: 2022 Tipo de documento: Article