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Reward-based reinforcement learning is altered among individuals with a history of major depressive disorder and psychomotor retardation symptoms.
Letkiewicz, Allison M; Cochran, Amy L; Mittal, Vijay A; Walther, Sebastian; Shankman, Stewart A.
Afiliação
  • Letkiewicz AM; Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA. Electronic address: allison.letkiewicz@northwestern.edu.
  • Cochran AL; Department of Mathematics, University of Wisconsin, Madison, WI, USA; Department of Population Health Sciences, University of Wisconsin, Madison, WI, USA.
  • Mittal VA; Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA; Department of Psychology, Northwestern University, Evanston, IL, USA.
  • Walther S; Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
  • Shankman SA; Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA; Department of Psychology, Northwestern University, Evanston, IL, USA.
J Psychiatr Res ; 152: 175-181, 2022 08.
Article em En | MEDLINE | ID: mdl-35738160
Reward-based reinforcement learning impairments are common in major depressive disorder, but it is unclear which aspects of reward-based reinforcement learning are disrupted in remitted major depression (rMDD). Given that the neurobiological substrates that implement reward-based RL are also strongly implicated in psychomotor retardation (PmR), the present study sought to test whether reward-based reinforcement learning is altered in rMDD individuals with a history of PmR. Three groups of individuals (1) rMDD with past PmR (PmR+, N = 34), (2) rMDD without past PmR (PmR-, N = 44), and (3) healthy controls (N = 90) completed a reward-based reinforcement learning task. Computational modeling was applied to test for group differences in model-derived parameters - specifically, learning rates and reward sensitivity. Compared to controls, rMDD PmR + exhibited lower learning rates, but not reduced reward sensitivity. By contrast, rMDD PmR- did not significantly differ from controls on either of the model-derived parameters. Follow-up analyses indicated that the results were not due to current psychopathology symptoms. Results indicate that a history of PmR predicts altered reward-based reinforcement learning in rMDD. Abnormal reward-related reinforcement learning may reflect a scar of past depressive episodes that contained psychomotor symptoms, or a trait-like deficit that preceded these episodes.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior Idioma: En Ano de publicação: 2022 Tipo de documento: Article