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Macrocycle-stabilization of its interaction with 14-3-3 increases plasma membrane localization and activity of CFTR.
Stevers, Loes M; Wolter, Madita; Carlile, Graeme W; Macdonald, Dwight; Richard, Luc; Gielkens, Frank; Hanrahan, John W; Thomas, David Y; Chakka, Sai Kumar; Peterson, Mark L; Thomas, Helmut; Brunsveld, Luc; Ottmann, Christian.
Afiliação
  • Stevers LM; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.
  • Wolter M; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.
  • Carlile GW; Cystic Fibrosis Translational Research Centre, Department of Biochemistry and Physiology, McGill University, Montreal, QC, Canada.
  • Macdonald D; Cyclenium Pharma Inc., 7171 rue Frederick Banting, Montreal, Quebec, Canada.
  • Richard L; Cyclenium Pharma Inc., 7171 rue Frederick Banting, Montreal, Quebec, Canada.
  • Gielkens F; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.
  • Hanrahan JW; Cystic Fibrosis Translational Research Centre, Department of Biochemistry and Physiology, McGill University, Montreal, QC, Canada.
  • Thomas DY; Cystic Fibrosis Translational Research Centre, Department of Biochemistry and Physiology, McGill University, Montreal, QC, Canada.
  • Chakka SK; Cyclenium Pharma Inc., 7171 rue Frederick Banting, Montreal, Quebec, Canada.
  • Peterson ML; Cyclenium Pharma Inc., 7171 rue Frederick Banting, Montreal, Quebec, Canada.
  • Thomas H; Cyclenium Pharma Inc., 7171 rue Frederick Banting, Montreal, Quebec, Canada.
  • Brunsveld L; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.
  • Ottmann C; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands. c.ottmann@tue.nl.
Nat Commun ; 13(1): 3586, 2022 06 23.
Article em En | MEDLINE | ID: mdl-35739107
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulador de Condutância Transmembrana em Fibrose Cística / Fibrose Cística Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulador de Condutância Transmembrana em Fibrose Cística / Fibrose Cística Idioma: En Ano de publicação: 2022 Tipo de documento: Article