Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage.
Int J Mol Sci
; 23(12)2022 Jun 09.
Article
em En
| MEDLINE
| ID: mdl-35742924
ABSTRACT
Intracerebral hemorrhage (ICH) is a complex and heterogeneous disease, and there is no effective treatment. Spontaneous ICH represents the final manifestation of different types of cerebral small vessel disease, usually categorized as lobar (mostly related to cerebral amyloid angiopathy) and nonlobar (hypertension-related vasculopathy) ICH. Accurate phenotyping aims to reflect these biological differences in the underlying mechanisms and has been demonstrated to be crucial to the success of genetic studies in this field. This review summarizes how current knowledge on genetics and epigenetics of this devastating stroke subtype are contributing to improve the understanding of ICH pathophysiology and their potential role in developing therapeutic strategies.
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Base de dados:
MEDLINE
Assunto principal:
Angiopatia Amiloide Cerebral
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Acidente Vascular Cerebral
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Hipertensão
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article