KLF10 Functions as an Independent Prognosis Factor for Gastric Cancer.
Medicina (Kaunas)
; 58(6)2022 May 26.
Article
em En
| MEDLINE
| ID: mdl-35743973
ABSTRACT
Background and Objectives:
Kruppel-like factor 10 (KLF10) participates in the tumorigenesis of several human cancers by binding to the GC-rich region within the promoter regions of specific genes. KLF10 is downregulated in human cancers. However, the role of KLF10 in gastric cancer formation remains unclear. Materials andMethods:
In this study, we performed immunohistochemical staining for KLF10 expression in 121 gastric cancer sections.Results:
The loss of KLF10 expression was correlated with advanced stages and T status. Kaplan-Meier analysis revealed that patients with higher KLF10 levels had longer overall survival than those with lower KLF10 levels. Univariate analysis revealed that in patients with gastric cancer, advanced stages and low KLF10 levels were associated with survival. Multivariate analysis indicated that age, gender, advanced stages, and KLF10 expression were independent prognostic factors of the survival of patients with gastric cancer. After adjusting for age, gender, and stage, KLF10 expression was also found to be an independent prognostic factor in the survival of patients with gastric cancer.Conclusion:
Our results collectively suggested that KLF10 may play a critical role in gastric cancer formation and is an independent prognosis factor of gastric cancer.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Fatores de Transcrição de Resposta de Crescimento Precoce
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article