Orchestrating ribosomal RNA folding during ribosome assembly.
Bioessays
; 44(8): e2200066, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35751450
ABSTRACT
Construction of the eukaryotic ribosome is a complex process in which a nascent ribosomal RNA (rRNA) emerging from RNA Polymerase I hierarchically folds into a native three-dimensional structure. Modular assembly of individual RNA domains through interactions with ribosomal proteins and a myriad of assembly factors permit efficient disentanglement of the error-prone RNA folding process. Following these dynamic events, long-range tertiary interactions are orchestrated to compact rRNA. A combination of genetic, biochemical, and structural studies is now providing clues into how a nascent rRNA is transformed into a functional ribosome with high precision. With this essay, we aim to draw attention to the poorly understood process of establishing correct RNA tertiary contacts during ribosome formation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Ribossômico
/
Dobramento de RNA
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article