Lycorine and organ protection: Review of its potential effects and molecular mechanisms.
Phytomedicine
; 104: 154266, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-35752077
ABSTRACT
BACKGROUND:
Multiorgan dysfunction, especially sepsis-related multiorgan damage, remains a major cause of high mortality in the late stages of infection and a great clinical challenge. In recent years, natural drugs have received widespread attention because of their low cost, wide sources, high efficacy, low toxicity, and limited side effects. Lycorine, a natural compound extracted from Amaryllidaceae, exhibits multiple pharmacological activities, including in the regulation of autophagy and the induction of cancer cell apoptosis, and has anti-inflammatory, antifungal, antiviral, antimalarial, and antitumor activities. However, studies on lycorine have mainly focused on its antitumor properties, and research on its use for organ protection, especially in sepsis-related organ injury, is relatively limited.PURPOSE:
To review and discuss the effects and mechanisms of lycorine in the treatment of multi-organ dysfunction, especially sepsis.METHODS:
Literature searches in electronic databases, such as Web of Science, Science Direct, PubMed, Google Scholar, and Scopus, were performed using 'Lycorine', 'Amaryllidaceae', 'Pharmacology', 'Pharmacokinetics', 'Anti-inflammation', 'Autophagy', 'Apoptosis', 'Anti-microbial and anti-parasitic', 'Antitumor', 'Organ protection', and 'Sepsis' as keywords, the correlated literature was extracted and conducted from the databases mentioned above.RESULTS:
By summarizing the progress made in existing research, we found that the general effects of lycorine involve the regulation of autophagy and the induction of cancer cell apoptosis, and anti-inflammatory, antifungal, antiviral, antimalarial, and antitumor effects; through these pathways, the compound can ameliorate organ damage. In addition, lycorine was found to have an important effect on organ damage in sepsis.CONCLUSION:
Lycorine is a promising natural organ protective agent. This review will provide a new theoretical basis for the treatment of organ protection, especially in sepsis.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcaloides de Amaryllidaceae
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Amaryllidaceae
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Antimaláricos
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article