Effect of X irradiation on adenosine triphosphate and glucose-6-phosphate dehydrogenase in the CaNT mouse tumor.
Radiat Res
; 110(2): 305-9, 1987 May.
Article
em En
| MEDLINE
| ID: mdl-3575658
ABSTRACT
The levels of adenosine triphosphate (ATP) in the transplantable CaNT murine tumor grown in CBA mice at various times following 5, 10, and 15 Gy X rays (100 kVp) were increased within 45 min. Maximal ATP levels occurred at 2.5 h following the 10 Gy dose (3.8 times that of unirradiated controls), returning almost to control levels by 13 h after irradiation. The specific activity of glucose-6-phosphate dehydrogenase (G-6-PDH) after 10 Gy increased about 1.5-fold 1 h after irradiation, returning to control levels by 48 h. It is suggested that the increased ATP following irradiation might play a major role in energy provision when cellular repair processes are able to operate. The increased G-6-PDH activity after irradiation may reflect enhanced metabolism associated with cellular repair mechanisms.
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Base de dados:
MEDLINE
Assunto principal:
Trifosfato de Adenosina
/
Glucosefosfato Desidrogenase
/
Neoplasias Experimentais
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article