New thiophene, thienopyridine and thiazoline-based derivatives: Design, synthesis and biological evaluation as antiproliferative agents and multitargeting kinase inhibitors.

Alamshany, Zahra M; Tashkandi, Nada Y; Othman, Ismail M M; Anwar, Manal M; Nossier, Eman S

Alamshany, Zahra M; Tashkandi, Nada Y; Othman, Ismail M M; Anwar, Manal M; Nossier, Eman S.

Afiliação

Alamshany ZM; Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21551, P.O. Box 42805, Saudi Arabia.
Tashkandi NY; Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21551, P.O. Box 42805, Saudi Arabia.
Othman IMM; Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut 71524, Egypt.
Anwar MM; Department of Therapeutic Chemistry, National Research Centre, Dokki, Cairo 12622, Egypt. Electronic address: manal.hasan52@live.com.
Nossier ES; Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt. Electronic address: dr.emannossier@gmail.com.

Bioorg Chem ; 127: 105964, 2022 10.

Article em En | MEDLINE | ID: mdl-35759881

Assuntos

Antineoplásicos; Receptor 2 de Fatores de Crescimento do Endotélio Vascular; Antineoplásicos/química; Linhagem Celular Tumoral; Proliferação de Células; Ensaios de Seleção de Medicamentos Antitumorais; Receptores ErbB/metabolismo; Simulação de Acoplamento Molecular; Estrutura Molecular; Inibidores de Proteínas Quinases; Relação Estrutura-Atividade; Tienopiridinas/farmacologia; Tiofenos/química

Palavras-chave

Antiproliferative activity; Apoptosis; Cell cycle; EGFR; Pim-1; Proapoptotic potential; Thiazoline; Thienopyridine; Thiophene; VEGFR-2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor 2 de Fatores de Crescimento do Endotélio Vascular / Antineoplásicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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