Mitochondrial Toxicity of Organic Arsenicals.
Methods Mol Biol
; 2497: 173-184, 2022.
Article
em En
| MEDLINE
| ID: mdl-35771442
ABSTRACT
Arsenic is either notorious toxicant or miracle cure for acute promyelocytic leukemia and several other diseases. It interacts with mitochondria directly or indirectly, by interacting with mitochondrial enzymes, such as respiratory chain complexes and tricarboxylic acid cycle proteins, or affecting mitochondrial homeostasis via ROS or mitochondrial outer membrane permeabilization. Given the ubiquitous presence of mitochondria and indispensable role in cellular metabolism, arsenical-mitochondrial interactions may manifest clinical importance by revealing mechanism of disease curation, preventing severe side effects, and foreseeing potential health issues. Here, we described the interaction between isolated mitochondria and arsenicals.
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Base de dados:
MEDLINE
Assunto principal:
Arsenicais
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article