Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever.
Cell Immunol
; 378: 104572, 2022 08.
Article
em En
| MEDLINE
| ID: mdl-35772315
ABSTRACT
We have previously demonstrated that Mucosal-Associated Invariant T (MAIT) cells secrete multiple cytokines after exposure to Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever in humans. However, whether cytokine secreting MAIT cells can enhance or attenuate the clinical severity of bacterial infections remain debatable. This study characterizes human MAIT cell functions in subjects participating in a wild-type S. Typhi human challenge model. Here, we found that MAIT cells exhibit distinct functional signatures associated with protection against typhoid fever. We also observed that the cytokine patterns of MAIT cell responses, rather than the average number of cytokines expressed, are more predictive of typhoid fever outcomes. These results might enable us to objectively, based on functional parameters, identify cytokine patterns that may serve as predictive biomarkers during natural infection and vaccination.
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Base de dados:
MEDLINE
Assunto principal:
Febre Tifoide
/
Células T Invariantes Associadas à Mucosa
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article