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Verteporfin protects against Th17 cell-mediated EAE independently of YAP inhibition.
Brosinsky, Paulin; Leister, Hanna; Cheng, Nan; Varelas, Xaralabos; Visekruna, Alexander; Luu, Maik.
Afiliação
  • Brosinsky P; Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
  • Leister H; Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
  • Cheng N; Department of Biochemistry, Boston University School of Medicine, Massachusetts, United States of America.
  • Varelas X; Department of Biochemistry, Boston University School of Medicine, Massachusetts, United States of America.
  • Visekruna A; Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
  • Luu M; Institute for Medical Microbiology and Hygiene, Philipps-University Marburg, Marburg, Germany.
Eur J Immunol ; 52(9): 1523-1526, 2022 09.
Article em En | MEDLINE | ID: mdl-35776890
ABSTRACT
The known YAP inhibitor verteporfin is capable of repressing IL-17A production in Th17 cells. However, this effect is mediated independently of YAP and can ameliorate Th17-mediated experimental autoimmune encephalomyelitis (EAE) upon in vivo administration. The data suggest verteprofin's mode of action for the design of novel therapeutic autoimmune disease intervention.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encefalomielite Autoimune Experimental / Células Th17 Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encefalomielite Autoimune Experimental / Células Th17 Idioma: En Ano de publicação: 2022 Tipo de documento: Article