Verteporfin protects against Th17 cell-mediated EAE independently of YAP inhibition.
Eur J Immunol
; 52(9): 1523-1526, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35776890
ABSTRACT
The known YAP inhibitor verteporfin is capable of repressing IL-17A production in Th17 cells. However, this effect is mediated independently of YAP and can ameliorate Th17-mediated experimental autoimmune encephalomyelitis (EAE) upon in vivo administration. The data suggest verteprofin's mode of action for the design of novel therapeutic autoimmune disease intervention.
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Base de dados:
MEDLINE
Assunto principal:
Encefalomielite Autoimune Experimental
/
Células Th17
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article