Huge discrepancy between serum immunoglobulin concentration and proteinemia due to heavy chain disease.
Clin Biochem
; 108: 10-13, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-35779576
ABSTRACT
Immunoassays are widely used in clinical laboratories because of their ease of use and low cost. These tests are based on antigen-antibody binding. However, clinicians and laboratory personnel may be confronted with immunoassay interference leading to difficulties in medical care. Here, we report a huge analytical discrepancy with IgG concentration higher than proteinemia in a 75-year-old man. Serum electrophoresis and immunofixation diagnosed γ-heavy chain disease. After investigation by different methods, the assay discrepancy was still present. We hypothesize that the interference is related to the truncated immunoglobulin secreted by the lymphoproliferative disorder.
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MEDLINE
Assunto principal:
Doença das Cadeias Pesadas
Idioma:
En
Ano de publicação:
2022
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Article