Phenylethanoid Glycosides of Cistanche Improve Learning and Memory Disorders in APP/PS1 Mice by Regulating Glial Cell Activation and Inhibiting TLR4/NF-&#954;B Signaling Pathway.

Wang, Chunhui; Ye, Hongxia; Zheng, Yanjie; Qi, Yanqiang; Zhang, Mengyu; Long, Yan; Hu, Yanli

Phenylethanoid Glycosides of Cistanche Improve Learning and Memory Disorders in APP/PS1 Mice by Regulating Glial Cell Activation and Inhibiting TLR4/NF-κB Signaling Pathway.

Wang, Chunhui; Ye, Hongxia; Zheng, Yanjie; Qi, Yanqiang; Zhang, Mengyu; Long, Yan; Hu, Yanli.

Afiliação

Wang C; Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Department of Pharmacology, Shihezi University, Shihezi, 832000, Xinjiang, People's Republic of China.
Ye H; Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Department of Pharmacology, Shihezi University, Shihezi, 832000, Xinjiang, People's Republic of China.
Zheng Y; Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Department of Pharmacology, Shihezi University, Shihezi, 832000, Xinjiang, People's Republic of China.
Qi Y; Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Department of Pharmacology, Shihezi University, Shihezi, 832000, Xinjiang, People's Republic of China.
Zhang M; Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Department of Pharmacology, Shihezi University, Shihezi, 832000, Xinjiang, People's Republic of China.
Long Y; Central Laboratory, Shenzhen Sami Medical Center, Shenzhen, China.
Hu Y; Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Department of Pharmacology, Shihezi University, Shihezi, 832000, Xinjiang, People's Republic of China. hyl_pha@shzu.edu.cn.

Neuromolecular Med ; 25(1): 75-93, 2023 03.

Article em En | MEDLINE | ID: mdl-35781783

Assuntos

Doença de Alzheimer; Cistanche; Camundongos; Animais; NF-kappa B/metabolismo; Cistanche/metabolismo; Receptor 4 Toll-Like; Glicosídeos/farmacologia; Glicosídeos/uso terapêutico; Glicosídeos/metabolismo; Transdução de Sinais/fisiologia; Transtornos da Memória/tratamento farmacológico; Transtornos da Memória/metabolismo; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/metabolismo; Microglia/metabolismo

Palavras-chave

Alzheimer's disease; Cistanche; Glial cells; Neuroinflammation; Synapse

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cistanche / Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cistanche / Doença de Alzheimer Idioma: En Ano de publicação: 2023 Tipo de documento: Article