Istradefylline, an adenosine A2a receptor antagonist, inhibits the CD4<sup>+</sup> T-cell hypersecretion of IL-17A and IL-8 in humans.

Tokano, Mieko; Kawano, Masaaki; Takagi, Rie; Matsushita, Sho

Istradefylline, an adenosine A2a receptor antagonist, inhibits the CD4⁺ T-cell hypersecretion of IL-17A and IL-8 in humans.

Tokano, Mieko; Kawano, Masaaki; Takagi, Rie; Matsushita, Sho.

Afiliação

Tokano M; Departments of Allergy and Immunology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.
Kawano M; Department of Infectious Disease and Infection Control, Saitama Medical University, Moroyama, Japan.
Takagi R; Departments of Allergy and Immunology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.
Matsushita S; Departments of Allergy and Immunology, Faculty of Medicine, Saitama Medical University, Moroyama, Japan.

Immunol Med ; 45(4): 244-250, 2022 Dec.

Article em En | MEDLINE | ID: mdl-35790489

Assuntos

Antagonistas do Receptor A2 de Adenosina; Receptor A2A de Adenosina; Animais; Humanos; Camundongos; Antagonistas do Receptor A2 de Adenosina/farmacologia; Interleucina-17; Interleucina-8/farmacologia; Antagonistas de Receptores Purinérgicos P1/farmacologia; Leucócitos Mononucleares; Linfócitos T; Adenosina/farmacologia; Linfócitos T CD4-Positivos; Inflamação

Palavras-chave

Adenosine A2a receptor; SARS-CoV-2; Th17 cells; neutrophilic inflammation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor A2A de Adenosina / Antagonistas do Receptor A2 de Adenosina Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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