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Cinnamamide derivatives with 4-hydroxypiperidine moiety enhance effect of doxorubicin to cancer cells and protect cardiomyocytes against drug-induced toxicity through CBR1 inhibition mechanism.
Koczurkiewicz-Adamczyk, Paulina; Gasiorkiewicz, Bartosz; Piska, Kamil; Gunia-Krzyzak, Agnieszka; Jamrozik, Marek; Bucki, Adam; Sloczynska, Karolina; Bojdo, Patrycja; Wójcik-Pszczola, Katarzyna; Wladyka, Benedykt; Kolaczkowski, Marcin; Pekala, Elzbieta.
Afiliação
  • Koczurkiewicz-Adamczyk P; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland. Electronic address: paulina.koczurkiewicz@uj.edu.pl.
  • Gasiorkiewicz B; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
  • Piska K; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
  • Gunia-Krzyzak A; Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
  • Jamrozik M; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
  • Bucki A; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
  • Sloczynska K; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
  • Bojdo P; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
  • Wójcik-Pszczola K; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
  • Wladyka B; Department of Analytical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
  • Kolaczkowski M; Department of Medicinal Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
  • Pekala E; Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
Life Sci ; 305: 120777, 2022 Sep 15.
Article em En | MEDLINE | ID: mdl-35792180
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miócitos Cardíacos / Neoplasias Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miócitos Cardíacos / Neoplasias Idioma: En Ano de publicação: 2022 Tipo de documento: Article