Diastereoselective access to substituted oxetanes via hydrosilylation-iodocyclisation of homopropargylic alcohols.
Chem Commun (Camb)
; 58(60): 8376-8379, 2022 Jul 26.
Article
em En
| MEDLINE
| ID: mdl-35792361
ABSTRACT
The regio and stereoselective hydrosilylation of a variety of homopropargylic alcohols and their derivatives is described. The reaction is tolerant to a variety of sterically and electronically varied substrates, affording only the E-vinyl silane as a sole regioisomer. The application of the resultant vinyl silanes towards the diastereoselective synthesis of tetrasubstituted oxetanes is demonstrated.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Silanos
/
Álcoois
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article