Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from Ajuga decumbens and Structural Revision of Two 3,4-Epoxy Group-Containing Abietanes.
J Nat Prod
; 85(7): 1808-1815, 2022 07 22.
Article
em En
| MEDLINE
| ID: mdl-35796002
ABSTRACT
Two new 3,4-epoxy group-containing abietane diterpenoids (1 and 2), together with five known diterpenoids (3-7), were isolated from Ajuga decumbens. Their structures were elucidated by spectroscopic data analysis, NMR calculations, and X-ray diffraction experiments. The structures of two known abietane diterpenoids were revised based on NMR calculations and X-ray diffraction data. Notably, compound 4 specifically inhibited RSL3-induced ferroptosis with an EC50 of 56 nM by antioxidation. Moreover, 4 significantly decreased RSL3-induced lipid and cytosolic ROS accumulation and ferroptosis marker gene PTGS2 mRNA expression. This work reports the most potent natural inhibitor against ferroptosis found so far.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ajuga
/
Diterpenos
/
Ferroptose
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article