Quantitative glycoproteomics of high-density lipoproteins.
RSC Adv
; 12(29): 18450-18456, 2022 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-35799915
ABSTRACT
In this work, we developed a targeted glycoproteomic method to monitor the site-specific glycoprofiles and quantities of the most abundant HDL-associated proteins using Orbitrap LC-MS for (glyco)peptide target discovery and QqQ LC-MS for quantitative analysis. We conducted a pilot study using the workflow to determine whether HDL protein glycoprofiles are altered in healthy human participants in response to dietary glycan supplementation.
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MEDLINE
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En
Ano de publicação:
2022
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Article