Cross-Modal Plasticity in Brains Deprived of Visual Input Before Vision.
Annu Rev Neurosci
; 45: 471-489, 2022 07 08.
Article
em En
| MEDLINE
| ID: mdl-35803589
ABSTRACT
Unimodal sensory loss leads to structural and functional changes in both deprived and nondeprived brain circuits. This process is broadly known as cross-modal plasticity. The evidence available indicates that cross-modal changes underlie the enhanced performances of the spared sensory modalities in deprived subjects. Sensory experience is a fundamental driver of cross-modal plasticity, yet there is evidence from early-visually deprived models supporting an additional role for experience-independent factors. These experience-independent factors are expected to act early in development and constrain neuronal plasticity at later stages. Here we review the cross-modal adaptations elicited by congenital or induced visual deprivation prior to vision. In most of these studies, cross-modal adaptations have been addressed at the structural and functional levels. Here, we also appraise recent data regarding behavioral performance in early-visually deprived models. However, further research is needed to explore how circuit reorganization affects their function and what brings about enhanced behavioral performance.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Privação Sensorial
/
Plasticidade Neuronal
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article