Bioenergetics and Reactive Nitrogen Species in Bacteria.
Int J Mol Sci
; 23(13)2022 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-35806323
ABSTRACT
The production of reactive nitrogen species (RNS) by the innate immune system is part of the host's defense against invading pathogenic bacteria. In this review, we summarize recent studies on the molecular basis of the effects of nitric oxide and peroxynitrite on microbial respiration and energy conservation. We discuss possible molecular mechanisms underlying RNS resistance in bacteria mediated by unique respiratory oxygen reductases, the mycobacterial bcc-aa3 supercomplex, and bd-type cytochromes. A complete picture of the impact of RNS on microbial bioenergetics is not yet available. However, this research area is developing very rapidly, and the knowledge gained should help us develop new methods of treating infectious diseases.
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Base de dados:
MEDLINE
Assunto principal:
Citocromos
/
Espécies Reativas de Nitrogênio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article