Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity.

Mandour, Asmaa A; Nassar, Ibrahim F; Abdel Aal, Mohammed T; Shahin, Mahmoud A E; El-Sayed, Wael A; Hegazy, Maghawry; Yehia, Amr Mohamed; Ismail, Ahmed; Hagras, Mohamed; Elkaeed, Eslam B; Refaat, Hanan M; Ismail, Nasser S M

Synthesis, biological evaluation, and in silico studies of new CDK2 inhibitors based on pyrazolo[3,4-d]pyrimidine and pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold with apoptotic activity.

Mandour, Asmaa A; Nassar, Ibrahim F; Abdel Aal, Mohammed T; Shahin, Mahmoud A E; El-Sayed, Wael A; Hegazy, Maghawry; Yehia, Amr Mohamed; Ismail, Ahmed; Hagras, Mohamed; Elkaeed, Eslam B; Refaat, Hanan M; Ismail, Nasser S M.

Afiliação

Mandour AA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo, Egypt.
Nassar IF; Faculty of Specific Education, Ain Shams University (ASU), Cairo, Egypt.
Abdel Aal MT; Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt.
Shahin MAE; Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt.
El-Sayed WA; Chemistry Department, College of Science, Qassim University, Qassim, Saudi Arabia.
Hegazy M; Photochemistry Department, National Research Centre, Cairo, Egypt.
Yehia AM; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Ismail A; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Hagras M; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Elkaeed EB; Department of Pharmaceutical Organic Chemistry, College of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
Refaat HM; Department of Pharmaceutical Science, College of Pharmacy, Al Maarefa University, Riyadh, Saudi Arabia.
Ismail NSM; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo, Egypt.

J Enzyme Inhib Med Chem ; 37(1): 1957-1973, 2022 Dec.

Article em En | MEDLINE | ID: mdl-35815597

Assuntos

Antineoplásicos; Inibidores de Proteínas Quinases; Antineoplásicos/química; Proliferação de Células; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Simulação de Acoplamento Molecular; Estrutura Molecular; Pirazóis/química; Pirimidinas/química; Relação Estrutura-Atividade

Palavras-chave

ADMET; CDK2; Pyrazolopyrimidine; apoptosis; cytotoxicity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Antineoplásicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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