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Migraine in Patients Undergoing PFO Closure: Characterization of a Platelet-Associated Pathophysiological Mechanism: The LEARNER Study.
Trabattoni, Daniela; Brambilla, Marta; Canzano, Paola; Becchetti, Alessia; Teruzzi, Giovanni; Porro, Benedetta; Fiorelli, Susanna; Muratori, Manuela; Tedesco, Calogero C; Veglia, Fabrizio; Montorsi, Piero; Bartorelli, Antonio L; Tremoli, Elena; Camera, Marina.
Afiliação
  • Trabattoni D; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Brambilla M; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Canzano P; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Becchetti A; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Teruzzi G; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Porro B; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Fiorelli S; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Muratori M; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Tedesco CC; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Veglia F; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Montorsi P; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Bartorelli AL; Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, Italy.
  • Tremoli E; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Camera M; Dipartimento di Scienze Biomediche e Cliniche L. Sacco, Università degli Studi di Milano, Milan, Italy.
JACC Basic Transl Sci ; 7(6): 525-540, 2022 Jun.
Article em En | MEDLINE | ID: mdl-35818509
ABSTRACT
The association between migraine and patent foramen ovale (PFO) has been documented. We aimed to investigate platelet activation, prothrombotic phenotype, and oxidative stress status of migraineurs with PFO on 100 mg/day aspirin, before and 6 months after PFO closure. Data show that, before PFO closure, expression of the classical platelet activation markers is comparable in patients and aspirin-treated healthy subjects. Conversely, MHA-PFO patients display an increased prothrombotic phenotype (higher tissue factorpos platelets and microvesicles and thrombin-generation potential), sustained by an altered oxidative stress status. This phenotype, which is more controlled by P2Y12-blockade than by aspirin, reverted after PFO closure together with a complete migraine remission. (pLatelEts And MigRaine iN patEnt foRamen Ovale [LEARNER]; NCT03521193).
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article