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Genome-wide DNA hypermethylation opposes healing in patients with chronic wounds by impairing epithelial-mesenchymal transition.
Singh, Kanhaiya; Rustagi, Yashika; Abouhashem, Ahmed S; Tabasum, Saba; Verma, Priyanka; Hernandez, Edward; Pal, Durba; Khona, Dolly K; Mohanty, Sujit K; Kumar, Manishekhar; Srivastava, Rajneesh; Guda, Poornachander R; Verma, Sumit S; Mahajan, Sanskruti; Killian, Jackson A; Walker, Logan A; Ghatak, Subhadip; Mathew-Steiner, Shomita S; Wanczyk, Kristen E; Liu, Sheng; Wan, Jun; Yan, Pearlly; Bundschuh, Ralf; Khanna, Savita; Gordillo, Gayle M; Murphy, Michael P; Roy, Sashwati; Sen, Chandan K.
Afiliação
  • Singh K; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Rustagi Y; Department of Surgery, The Ohio State University, Columbus, Ohio, USA.
  • Abouhashem AS; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Tabasum S; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Verma P; Sharkia Clinical Research Department, Ministry of Health, Zagazig, Sharkia, Egypt.
  • Hernandez E; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Pal D; Department of Surgery, The Ohio State University, Columbus, Ohio, USA.
  • Khona DK; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Mohanty SK; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Kumar M; Department of Surgery, The Ohio State University, Columbus, Ohio, USA.
  • Srivastava R; Department of Biomedical Engineering, Indian Institute of Technology Ropar, Punjab, India.
  • Guda PR; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Verma SS; Department of Surgery, The Ohio State University, Columbus, Ohio, USA.
  • Mahajan S; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Killian JA; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Walker LA; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Ghatak S; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Mathew-Steiner SS; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Wanczyk KE; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Liu S; Department of Physics, The Ohio State University, Columbus, Ohio, USA.
  • Wan J; Department of Physics, The Ohio State University, Columbus, Ohio, USA.
  • Yan P; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Bundschuh R; Department of Surgery, The Ohio State University, Columbus, Ohio, USA.
  • Khanna S; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Gordillo GM; Department of Surgery, The Ohio State University, Columbus, Ohio, USA.
  • Murphy MP; Indiana University Health Comprehensive Wound Center, Indiana Center for Regenerative Medicine and Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Roy S; Center for Computational Biology and Bioinformatics (CCBB), Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Sen CK; Center for Computational Biology and Bioinformatics (CCBB), Indiana University School of Medicine, Indianapolis, Indiana, USA.
J Clin Invest ; 132(17)2022 09 01.
Article em En | MEDLINE | ID: mdl-35819852
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metilação de DNA / Transição Epitelial-Mesenquimal Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metilação de DNA / Transição Epitelial-Mesenquimal Idioma: En Ano de publicação: 2022 Tipo de documento: Article