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A dual-targeting peptide facilitates targeting anti-inflammation to attenuate atherosclerosis in ApoE-/- mice.
Wu, Bo; Zhong, Yuanzhi; Chen, Jinmin; Pan, Xianmei; Fan, Xianglin; Chen, Peier; Fu, Chenxing; Ou, Caiwen; Chen, Minsheng.
Afiliação
  • Wu B; Department of Cardiology, Zhujiang Hospital of Southern Medical University, and Guangdong Provincial Center of Biomedical Engineering for Cardiovascular Diseases, Guangzhou, 510280, P. R. China. gzminsheng@vip.163.com.
  • Zhong Y; Department of Cardiology, Zhujiang Hospital of Southern Medical University, and Guangdong Provincial Center of Biomedical Engineering for Cardiovascular Diseases, Guangzhou, 510280, P. R. China. gzminsheng@vip.163.com.
  • Chen J; Cardiovascular Department of The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, P. R. China.
  • Pan X; Department of Cardiology, Zhujiang Hospital of Southern Medical University, and Guangdong Provincial Center of Biomedical Engineering for Cardiovascular Diseases, Guangzhou, 510280, P. R. China. gzminsheng@vip.163.com.
  • Fan X; Department of Cardiology, Zhujiang Hospital of Southern Medical University, and Guangdong Provincial Center of Biomedical Engineering for Cardiovascular Diseases, Guangzhou, 510280, P. R. China. gzminsheng@vip.163.com.
  • Chen P; Department of Cardiology, Zhujiang Hospital of Southern Medical University, and Guangdong Provincial Center of Biomedical Engineering for Cardiovascular Diseases, Guangzhou, 510280, P. R. China. gzminsheng@vip.163.com.
  • Fu C; Department of Cardiology, Zhujiang Hospital of Southern Medical University, and Guangdong Provincial Center of Biomedical Engineering for Cardiovascular Diseases, Guangzhou, 510280, P. R. China. gzminsheng@vip.163.com.
  • Ou C; Affiliated Dongguan Hospital, Southern Medical University (Dongguan People's Hospital), 523059, P. R. China.
  • Chen M; Department of Cardiology, Zhujiang Hospital of Southern Medical University, and Guangdong Provincial Center of Biomedical Engineering for Cardiovascular Diseases, Guangzhou, 510280, P. R. China. gzminsheng@vip.163.com.
Chem Commun (Camb) ; 58(62): 8690-8693, 2022 Aug 02.
Article em En | MEDLINE | ID: mdl-35833251
We report a peptidic dual-targeting drug delivery platform (integrins targeting and self-assembly instructed by matrix metalloproteinases) towards inflamed endothelial cells, which improved the anti-inflammatory ability of the loaded drug (i.e., puerarin) in vitro and thus improved the antiatherogenic effect of the loaded drug (i.e., puerarin) in vivo.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Endoteliais / Aterosclerose Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Endoteliais / Aterosclerose Idioma: En Ano de publicação: 2022 Tipo de documento: Article